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Malignant Hyperthermia-Like Syndrome and Carnitine Palmitoyltransferase II Deficiency with Heterozygous R503C Mutation
Anesthesia & Analgesia, 10/01/09
Hogan KJ et al. – The authors describe a child who developed a malignant hyperthermia–like syndrome after exposure to succinylcholine and halothane. Muscle rigidity, hypercarbia, and hyperkalemia were not observed. The patient was found to be heterozygous for a mutation in the carnitine palmitoyltransferase II gene (CPT2) encoding an arginine to cysteine substitution at amino acid 503 (R503C) with reduced activity of the enzyme.
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