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Pharmacology of Morphine in Obese Patients: Clinical Implications
Clinical Pharmacokinetics, 09/17/09

Linares CL et al. – Prescription of morphine depends on pain relief but the occurrence of respiratory adverse effects correlates with obesity, and is not currently taken into account. Variations in the volume of distribution, elimination half–life and oral clearance of morphine, as well as recent advances in the respective roles of drug–metabolizing enzymes, catechol–O–methyltransferase and the mu opioid receptor in morphine pharmacokinetics and pharmacodynamics, may contribute to differences between obese and non–obese patients. In addition, drug–drug interactions may alter the disposition of morphine and its glucuronide metabolites, which may either increase the risk of adverse effects or reduce drug efficacy.

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