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Gulle E et al. – The epidural treatment could be continued in 143 patients. Pruritus occurred in 53 patients with Breivik’s mixture compared to 12 in the ropivacaine/oxycodone group. Both regimes gave good pain control with average VAS regularly under 40 with a statisticallysignificant difference in favor of Breivik’s mixture. The number of pain breakthrough episodes did not differ between the groups. Pruritus could be decreased with a combination of epidural ropivacaine/oral oxycodone, at the price of a slightly higher pain level. A modification with slightly higher doses of oxycodone and/or ropivacaine may eliminate that difference. The results support the view that the pruritus is caused by epidural opiates.

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