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See Latest ArticlesMeta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment
Pain, 08/18/09
Walter C et al. – The authors found no consistent association between OPRM1 118A>G genotypes and most of the phenotypes in a heterogeneous set of eight clinical studies. Only weak evidence of an association with less nausea and of increased opioid dosage requirements in homozygous carriers of the G allele was obtained. This indicates that despite initially promising results, available evidence of the clinical relevance of the OPRM1 118A>G polymorphism does not withhold a meta–analysis. This discourages basing personalized therapeutic concepts of pain therapy on OPRM1 118A>G genotyping at the present state of evidence.
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