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Attenuation of Pulmonary Inflammation After Exposure To Blast Overpressure By N-Acetylcysteine Amide
Shock, 08/24/09
Chavko M et al. – The relatively higher inhibition of chemokine mRNAs compared with reduction in MPO activity and CD11b is in accordance with an antioxidant effect of NACA on reactive oxygen species (ROS) accumulation, rather than by an effect on neutrophil sequestration. The inhibition of HO–1 mRNA activation after blast was likely also related to the drug antioxidant effect.
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