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See Latest ArticlesEvodiamine represses hypoxia-induced inflammatory proteins expression and hypoxia-inducible factor 1[alpha] accumulation in raw264.7
Shock, 08/25/09
Liu YN et al. – The results suggest that the mechanism of repression of hypoxia–induced COX–2 expression by evodiamine is through the inhibition of HIF–1alpha at the translational level and is primarily mediated via dephosphorylation of Akt and p70S6K. Therefore, evodiamine could be an effective therapeutic agent against inflammatory diseases involving hypoxia.
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