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Iqbal A et al. – Pethidine can cause some side effects such as respiratory depression, hypotension, and postoperative nausea and vomiting. Therefore, prophylactic granisetron 40mcg.kg–1 intravenously may be administered without causing the adverse effect in patient with high expectancy of shivering and postoperative nausea and vomiting ranked sixth and second in morbidity clinical outcome.

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