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De Somer F – Despite major improvements in perfusion techniques over the past 50 years, it is still not possible to formulate a clear definition of what is meant by optimal perfusion. In part this is due to the lack of sufficient evidence–based data and in part because of the complex pathophysiology that takes place during cardiac surgery with cardiopulmonary bypass. Only a combined strategy can further improve cardiopulmonary bypass—related morbidity and mortality.

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