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Neostigmine Decreases Bupivacaine Use by Patient-Controlled Epidural Analgesia During Labor: A Randomized Controlled Study
Anesthesia & Analgesia, 07/21/09
Ross VH et al. – Adding epidural neostigmine 4 µg/mL reduces the hourly bupivacaine requirement by 19%–25% with patient–controlled epidural analgesia during labor. Administered as a bolus and by continuous infusion at the studied doses, epidural neostigmine does not cause nausea and does not induce uterine contractions or FHR abnormalities, but mild sedation can occur.
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