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Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study
Critical Care, 06/18/09
Dubin A et al. - Patients with septic shock showed severe sublingual microcirculatory alterations that failed to improve with the increases in MAP with norepinephrine. Nevertheless, there was a considerable interindividual variation. The results suggest that the increase in MAP above 65 mmHg is not an adequate approach to improve microcirculatory perfusion and might be harmful in some patients.
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