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See Latest ArticlesEarly down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury: a prospective cohort study
Critical Care, 06/12/09
Kirchhoff C et al. - It can be concluded that indeed as previously postulated an immediate hyperactivation of circulating monocytes is rapidly followed by a substantial paralysis of cell function. Moreover, the findings clearly demonstrate that the restricted capacity of monocytes to produce proinflammatory cytokines after severe injury is not only an in-vitro phenomenon but also undistinguishable associated with the onset of organ dysfunction in the clinical scenario.
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