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Role of fibrinogen-, factor VIII- and XIII-mediated clot propagation in gelatin haemodilution
Acta Anaesthesiologica Scandinavica, 06/16/09
Schramko AA et al. - Gelatin-induced whole-blood coagulation disorder in vitro is mainly dependent on the initial fibrinogen-fibrin interaction. The proposed mechanism might suggest not to reverse gelatin coagulopathy solely by fibrinogen administration. The administration of FFP, a mixture of different coagulation factors, reversed the gelatin-induced in vitro coagulopathy the best.
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