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See Latest ArticlesMode of cytotoxic action of nephrotoxic agents: oxidative stress and glutathione-dependent enzyme
BJU International, 06/03/09
Louie B et al. - The cytotoxic action of nephrotoxic agents appears to be triggered by oxidative stress, leading to Gly-I inactivation. As Gly-I plays a key role in cellular detoxification, its inactivation under oxidative stress probably becomes fatal to cells. However, cytoprotection provided with NAC is significant and might have implications in preventing renal cell injury mediated through nephrotoxic agents.
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