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Creagh-Brown BC et al. - Inhaled nitric oxide (iNO) results in preferential pulmonary vasodilatation and lowers pulmonary vascular resistance, augments hypoxic pulmonary vasoconstriction and improves oxygenation. These effects are harnessed in the therapeutic applications of iNO to patients with acute lung injury / adult respiratory distress syndrome; to those with acute right ventricular failure complicating cardiac surgery or acute pulmonary embolism; or in acute sickle chest crisis.

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