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See Latest ArticlesPredicting therapeutic efficacy - Experimental pain in human subjects
Brain Research Reviews, 04/20/09
Chizh BA et al. - The rational application of human experimental pain models in early clinical development is reviewed. Capsaicin, UV-irradiation and electrical stimulation methods have each been used to establish experimental hyperalgesia in Phase-I human volunteers and the application of these approaches is discussed in the context of several pharmacological examples. However, data generated from such studies must be integrated into a well-conceived and executed series of Phase-II efficacy trials in patients in order to derive maximal benefit. The challenges involved in optimal Phase-II/III trial design are reviewed with specific attention to the issues of sample size and placebo response. Finally, the application and potential of cortical EEG studies are discussed as an objective alternative to more conventional pain assessment tools with specific examples of how this technique has been applied to the study of NSAID and opiate-based therapeutics.
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HLA-DR expression and differential trafficking of monocyte subsets following low to intermediate risk surgery
Anaesthesia, 12/07/09
The relevance of childhood developmental factors to the efficacy of acupuncture on the affective component of back pain
Acupuncture in Medicine, 12/07/09
Increased H-reflex response induced by intramuscular electrical stimulation of latent myofascial trigger points
Acupuncture in Medicine, 12/07/09
Today in Pain Management...keeping you current
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Effects of perioperative intravenous low dose of ketamine on postoperative analgesia in children
European Journal of Anaesthesiology, 12/07/09
Systemic administration of lidocaine reduces morphine requirements and postoperative pain of patients undergoing thoracic surgery after propofol-remifentanil-based anaesthesia
European Journal of Anaesthesiology, 12/07/09
Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials
The Lancet, 12/07/09
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