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See Latest ArticlesBurn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: effects on tight junction structural proteins
Shock, 03/23/09
Costantini TW et al. - Confocal microscopy demonstrates that PTX attenuates the burn-induced reorganization of occludin and ZO-1 away from the tight junction. Pentoxifylline attenuates burn-induced intestinal permeability and decreases the breakdown and reorganization of intestinal occludin and ZO-1. Therefore, phosphodiesterase inhibition may be a useful adjunct strategy in the attenuation of burn-induced gut barrier injury.
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