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See Latest ArticlesAngiopoietin-1 in the treatment of ischemia and sepsis
Shock, 03/25/09
Novotny NM et al. - Angiogenic factors have been the focus of a great deal of research for the treatment of ischemic diseases. Described just more than 10 years ago, angiopoietin 1 (Ang-1) has shown promising results in I/R models. This review will focus on Ang-1 and its receptor, Tie-2, and the resultant intracellular signaling cascade; the complex relationship of Ang-1 and VEGF; the results of Ang-1 in I/R and sepsis models; the results of combination (Ang-1 and VEGF) therapies in I/R and sepsis models; and delivery mechanisms for angiogenic factors to ischemic heart.
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