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See Latest ArticlesHeme oxygenase-1 Induction in macrophages by a hemoglobin-based oxygen carrier reduces endotoxin-stimulated cytokine secretion
Shock, 02/19/09
Roach JP et al. - HBOC incubation of macrophages induced HO-1 expression, which reduced LPS-mediated cytokine release, and that MCP-1 and IL-6 secretion could be partially restored with ZnPP. These data encourage continued investigation into the role of HO-1 in protecting against posttraumatic organ dysfunction and the clinical potential of HBOC for HO-1 induction.
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