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(alpha)1-Adrenoceptors augment thermal hyperalgesia in mildly burnt skin
European Journal of Pain, 12/16/08
Drummond PD - The findings suggest that stimulation of cutaneous (alpha)1-adrenoceptors increased the excitability of heat-sensitized nociceptive afferents. As terazosin was more effective when administered in burnt skin, an inflammatory response induced by the burn injury may have facilitated access of adrenergic agents to (alpha)1-adrenoceptors.
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