Anesthesia Medical News about up-regulation of P2X3 receptors

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Functional up-regulation of P2X3 receptors in the chronically compressed dorsal root ganglion
Pain, 11/06/08

Xiang Z et al. - The currents were accompanied by the generation of action potentials – but only in the CCD neurons. U0126, a specific inhibitor of the MEK1/2, greatly down-regulated the enhanced current. Taken together, these observations suggest that enhanced purinergic responses after CCD are mediated by P2X3 receptors.

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