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Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis
Critical Care, 10/17/08
Weber SU et al. - In early severe sepsis a gene expression pattern with induction of the pro-apoptotic Bcl-2 family members Bim, Bid and Bak and a downregulation of the anti-apoptotic Bcl-2 and Bcl-xl was observed in peripheral blood. This constellation may affect cellular susceptibility to apoptosis and complex immune dysfunction in sepsis.
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