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The p38 mitogen-activated protein kinase pathway plays a critical role in par2-induced endothelial il-8 production and leukocyte adhesion
Shock, 10/17/08
Pan SL et al. - A member of a new subfamily of G protein-coupled receptors, protease-activated receptor 2 (PAR2), is highly expressed on endothelial cells and plays an important role in inflammation. The purpose of this study was to determine the molecular mechanism used by PAR2 to induce IL-8 production and thereby mediate cell adhesion.
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