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See Latest ArticlesRole of nuclear factor-[kappa]B-dependent induction of cytokines in the regulation of vasopressin V1A-receptors during cecal ligation and puncture-induced circulatory failure
Critical Care Medicine, 08/05/08
Schmidt C et al. - Data demonstrate that down-regulation of V1A-receptor expression during sepsis may be due to proinflammatory cytokines. Findings explain the failure of therapeutic strategies targeting single cytokines as well as the success of glucocorticoid therapy and define a critical role for NF-[kappa]B in the pathogenesis of septic shock.
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