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Pivotal role of glutathione depletion in plasma-induced endothelial oxidative stress during sepsis
Critical Care Medicine, 08/05/08
Huet O et al. - Study demonstrates that plasma-induced ROS production by HUVEC is associated with an intracellular decrease in reduced GSH. Both ROS levels and cell death decreased when N-acetylcysteine or GSH were added before exposing the cells to plasma. These data suggest a pivotal role of alterations in GSH in damage caused by sepsis-generated ROS in endothelial cell.
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