Effect of intraoperative lidocaine on anesthetic consumption, and bowel function, pain intensity, analgesic consumption and hospital stay after breast surgery

Korean Journal of Anesthesiology, 06/04/2012

Choi SJ et al. – Low dose intraoperative lidocaine infusion offered no beneficial effects on return of bowel function, opioid sparing, pain intensity and hospital stay after various breast plastic surgeries.


  • Sixty female patients, aged 20-60years, enrolled in this prospective study were randomly and equally divided to two groups.
  • One group (n=30) received a 1.5mg/kg bolus of lidocaine approximately 30min before incision followed by continuous infusion of lidocaine (1.5mg/kg/h) until skin closure (lidocaine group).
  • The other group (n=30) was untreated (control group).
  • Balanced inhalation (sevoflurane) anesthesia and multimodal postoperative analgesia were standardized.
  • End tidal sevoflurane concentration during surgery, time to the first flatus and defecation, visual analog pain scale (0-10), analgesic consumption and associated side effects at 24, 48, and 72h after surgery, hospital stay, and patient's general satisfaction were assessed.


  • Compared to the control group, intraoperative lidocaine infusion reduced by 5% the amount of sevoflurane required at similar bispectral index (P=0.014).
  • However, there were no significant effects of lidocaine regarding the return of bowel function, postoperative pain intensity, analgesic sparing and side effects at all time points, hospital stay, and level of patient's satisfaction for pain control.

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