Interleukin-18 levels reflect the long-term prognosis of acute lung injury and acute respiratory distress syndrome
Journal of Anesthesia, 06/04/2012
Makabe H et al. – The present data demonstrate an inverse correlation between serum interleukin (IL)–18 level and the P/F ratio, suggesting the possible involvement of IL–18 in the pathogenesis of respiratory failure in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Early–stage serum IL–18, IL–12, and tumor necrosis factor (TNF)–α levels appear to reflect the >60–day prognosis in patients with ALI/ARDS.
The study subjects were 38 patients with acute respiratory failure treated at the institution during the 4-year period from April 2004 to March 2008.
The underlying clinical condition was defined as acute respiratory distress syndrome (ARDS; n=12) or acute lung injury (ALI; n=26).
The serum levels of interleukin (IL)-18, IL-12, and tumor necrosis factor (TNF)-α were measured by enzyme-linked immunosorbent assays.
The ARDS group showed significantly higher serum levels of IL-18, IL-12, and TNF-α even at an early stage after disease onset compared with the ALI group.
A negative correlation was noted between the PaO2/FIO2 ratio (P/F ratio) and serum IL-18 level.
Analysis of all 38 patients with ALI/ARDS revealed a 30-day mortality rate of 7.9 %, 60-day mortality rate of 15.8 %, and 90-day mortality rate of 18.4 %.
The early-stage serum levels of IL-18, IL-12, and TNF-α were significantly higher in the non-survivors at 60 and 90days, but not at 30days, than in the corresponding survivors.
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.