Do induced hypertension and hypotension affect stroke volume variation in man
Journal of Clinical Anesthesia, 05/04/2012
Wajima Z et al. – Stroke volume variation (SVV) does not misinterpret preload dependency assessment of patients receiving medications to increase or to lower blood pressure.
31 ASA physical status 1 and 2 patients, aged 39-62years, who were scheduled for elective surgery.
The authors conducted three studies: a pressor test study, a depressor test study, and an induced hypotensive anesthesia study.
In the pressor test, patients received a bolus of phenylephrine 0.001mg/kg to increase systolic arterial pressure (SAP) by 30% to 40% compared with baseline.
In the depressor test, patients received a bolus of nitroglycerine 0.005mg/kg to decrease SAP by 30% to 40% compared with baseline.
In the induced hypotensive anesthesia test, patients received intravenous (IV) nitroglycerine continuously until mean arterial pressure (MAP) was reduced to 60-70mmHg.
When arterial pressure reached the target pressure for each study type, SVV and other parameters were recorded.
Induced hypertension (pressor test) decreased SVV, while induced hypotension (depressor test) and induced hypotensive anesthesia increased SVV.