The antiemetic effect of midazolam or/and ondansetron added to intravenous patient controlled analgesia in patients of pelviscopic surgery

Korean Journal of Anesthesiology, 04/30/2012

Midazolam added to patient–controlled analgesia (PCA) using fentanyl proved more effective than ondansetron in preventing postoperative nausea and vomiting (PONV) without adverse effects.


  • The PCA using 20µg/kg of fentanyl was started in all groups postoperatively.
  • A dose of 16mg of ondansetron was added to the PCA of group O (n=30).
  • A dose of 5mg of midazolam was added to the PCA of group M (n=30).
  • While 16mg of ondansetron and 5mg of midazolam were added to the PCA of group MO (n=30).
  • Total volume of the PCA was 60ml, and the PCA system was programmed to deliver 0.5ml/h of continuous doses and a 0.5ml bolus on demand, with a 15minutes lockout interval.
  • The incidence of postoperative nausea and vomiting (PONV), sedation score, visual analog scale (VAS) for pain, and rescue drug dose for PONV were investigated at the postanesthesia care unit (PACU), 6hours, and 24hours after recovery.


  • The incidence of PONV in group MO was significantly lower than in group O at PACU, 24hours after recovery (P<0.05).
  • The sedation score and VAS pain score showed no differences among all groups.

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