Pain relief after total hip replacement: oral CR oxycodone plus IV paracetamol versus epidural levobupivacaine and sufentanil. A randomized controlled trial
Minerva Anestesiologica, 04/27/2012Divella M et al.
Oral controlled release (CR) oxycodone plus IV paracetamol was as effective as epidural levobupivacaine and sufentanil for postoperative pain relief after total hip replacement (THR).
Two hundred and sixty patients undergoing THR were randomized into two groups.
A group of 130 patients (EPI) under epidural anesthesia followed by continuous infusion of levobupivacaine 0.125% and sufentanil 0.7mcg/mL at 7mL/h was compared with a group (OXY) of 130 patients under spinal anesthesia and oral CR oxycodone 10mg/q12h plus IV paracetamol 1g/q6h.
Pain intensity at rest and dynamic by visual analogue scores (VAS), rescue dose consumption and side effects of three postoperative days (POD) were collected and analyzed with Mann–Withney test (P<0.05 was considered significant).
VAS values at rest were similar in both groups at POD#1, significantly lower in the OXY group either at POD#2 (P=0.018) and POD#3 (P=0.001).
Dynamic VAS values were significantly lower in the EPI group at POD#1 (P=0.001), similar for both groups at POD#2 and significantly lower in the OXY group at POD#3 (P=0.026) than the comparing group.
Rescue dose consumption was significantly lower in the EPI group during the POD#1 (P=0.009), similar for both groups at POD#2 and higher in the EPI at POD#3 (P=0.008).
The incidence of vomiting was similar for the two groups.
Nausea was more frequent in the OXY group at POD#3 and more hypotension events occurred in the OXY group at POD#2.
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.