Decreased Plasma Concentrations of Apolipoprotein M in Sepsis and Systemic Inflammatory Response Syndromes
Critical Care, 04/24/2012
Kumaraswamy SB et al. – During sepsis and systemic inflammatory response syndrome (SIRS), the plasma concentrations of apolipoprotein M (apoM) drop dramatically, the degree of decrease reflecting the severity of the disease. As a carrier for barrier protective sphingosine–1–phosphate (S1P) in high–density lipoprotein (HDL), the decrease in apoM could contribute to the increased vascular leakage observed in sepsis and SIRS.
Plasma samples from patients with:
Severe sepsis with shock (n=26)
Severe sepsis without shock (n=44)
Infections without SIRS (n=43)
SIRS without infection (n=20) were analyzed.
The concentrations of apoM, apoA1, and apoB were measured with ELISAs.
Total- HDL- and LDL-cholesterol concentrations were measured with a commercial HDL/LDL cholesterol test.
ApoM concentrations correlated negatively to acute phase markers.
Thus, apoM behaved as a negative acute phase protein.
Decreased values were observed in all patients groups (P<0.0001), the most drastic decreases observed in the severely sick patients.
ApoM levels correlated strongly to those of apoA1, apoB, HDL- and LDL cholesterol.
The HDL- and LDL cholesterol levels were low in all patients groups, as compared to controls (P<0.0001), in particular HDL-cholesterol.
ApoA1 and apoB concentrations were only low in the more severely affected patients.
MDLinx connects healthcare professionals and patients to tomorrow's important medical news, while providing the pharmaceutical and healthcare industries with highly targeted interactive marketing, education, content, and medical research solutions.