Effect of epidural dexmedetomidine on intraoperative awareness and post-operative pain after one-lung ventilation

Acta Anaesthesiologica Scandinavica, 01/25/2010

The authors compared the effects of a dexmedetomidine–bupivacaine mixture with plain bupivacaine for thoracic epidural anaesthesia on intraoperative awareness and analgesic benefits, when combined with superficial isoflurane anaesthesia (<0.05 maximum alveolar concentration) in patients undergoing thoracic surgery with one–lung ventilation (OLV). In thoracic surgery with OLV, the use of epidural dexmedetomidine decreases the anaesthetic requirements significantly, prevents awareness during anaesthesia and improves intraoperative oxygenation and post–operative analgesia.

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