Efficacy and safety of lornoxicam compared with placebo and diclofenac in acute sciatica/lumbo-sciatica: an analysis from a randomised, double-blind, multicentre, parallel-group study
International Journal of Clinical Practice, 10/12/2009
Herrmann WA et al. – These data indicate that the analgesic efficacy of lornoxicam (LNX) is superior to placebo and similar to diclofenac in acute sciatica/lumbo–sciatica. - Male or female patients (n = 171) aged 18–70 years with acute sciatica or lumbo–sciatica.
- The dosage of study treatment was 8–24 mg/day LNX, 100–150 mg/day diclofenac or placebo.
Results - In total, 164 patients completed the study ... tolerability was rated as very good/good by 93% of the patients.
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Lumbar radiculopathy. Epidural injection of steroid and pain medication versus placebo
Evidence-Based Spine Surgery, 09/10/2009
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Epidural steroid injections for treatment of sciatica did not confer significant additional benefit over placebo injection in patients who had had symptoms for less than one year. While steroid injections may ... between active and placebo treatments after 4 weeks of follow–up. Treatment of sciatica with epidural steroids has exhibited no significant functional benefit, nor does it reduce the need for surgery. Outcomes varied minimally by injection site across studies, not based on direct comparisons
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Chordoma of the Lumbar Spine Presenting as Sciatica and Treated with Vertebroplasty
Cardiovascular and Interventional Radiology, 09/25/2009
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Chatterjee S et al. – Vertebroplasty was performed and resulted in immediate pain relief. For patients with painful lumbar chordoma who are unwilling to undergo surgery, vertebroplasty can play a palliative
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Review: back exercise interventions prevent self-reported episodes of back problems in adults but ergonomic education does not
Evidence-Based Medicine, 08/13/2009
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Included studies evaluated any intervention for preventing episodes of back problems (back symptoms or limited activity because of back pain or sciatica) in people 18–65 years of age. Studies that reported changes in anatomy or physiology or knowledge outcomes, or evaluated patient treatment to
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Disordered Sacroiliac Joint Pain
Practical Pain Management, 09/28/2009
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bears over 100 pounds or more. It is critical that this disorder be recognized because it is not only a common cause of chronic back pain and sciatica, it may be associated or possibly even causative of a number of common musculo–skeletal conditions. The most common manifestation is chronic
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Low back pain may be caused by disturbed pain regulation: A cross-sectional study in low back pain patients using tender point examination
European Journal of Pain, 10/08/2009
it may be caused by disturbed pain regulation. Methods - Patients sick–listed 3–16 weeks due to LBP with or without sciatica completed a questionnaire and went through a clinical low back examination and TP examination.
- Of 326 patients 111 had verified nerve root
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Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation
Arthritis Research & Therapy, 11/12/2009
may affect the resorption of DH under certain conditions. Methods- DH tissue harvested from patients undergoing surgery for sciatica
- Samples thoroughly washed
- Diced explants cultured ex-vivo in 1) 0.5 ml DMEM 10% FCS (controls), 2) recombinant IL-1Ra (100 ng/ ml
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