Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. Doctors and the DEA Free full text
Top Ten Searches
epidural double lumen lidoderm scopolamine phenylepherene sciatica est pain control pregnancy intubationYour Article Summary
See Latest ArticlesMexiletine and Lidocaine Suppress the Excitability of Dorsal Horn Neurons
Anesthesia & Analgesia, 06/26/09
Olschewski A et al. - In clinically relevant concentrations, lidocaine and mexiletine reduced the excitability of sensory dorsal horn neurons via a blockade of Na+ and K+ channels. The authors' work confirms that, in addition to the peripheral effects of lidocaine and mexiletine, modulation of voltage-gated ion channels in the central nervous system contributes to the antinociceptive effects of these drugs used in pain therapy.
Related Articles
Ondansetron added to lidocaine for intravenous regional anaesthesia
European Journal of Anaesthesiology, 11/12/09
Relevance Score: 87%
Use of lidocaine patches for neuropathic pain in a comprehensive cancer centre
Pain Research and Management, 10/28/09
Relevance Score: 87%
An Ultra-Low Dose of Naloxone Added to Lidocaine or Lidocaine-Fentanyl Mixture Prolongs Axillary Brachial Plexus Blockade
Anesthesia & Analgesia, 10/26/09
Relevance Score: 87%
Incidence of Low Back Pain After Spinal Anaesthesia With and Without Local Infiltration with Lidocaine
Journal of Anaesthesiology Clinical Pharmacology, 10/05/09
Relevance Score: 87%
Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy
Acta Anaesthesiologica Scandinavica, 11/18/09
Relevance Score: 85%
Today in Pain Management...keeping you current
Receive free subspecialty "5-minute updates" via email
Dienogest: a new therapeutic agent for the treatment of endometriosis *TEST*
Women's Health, 12/17/09
Comparative Study of Greater Palatine Nerve Block and Intravenous Pethidine for Postoperative Analgesia in Children Undergoing Palatoplasty
Indian Journal of Anaesthesia, 12/17/09
Ultrasound-aided unilateral epidural block for single lower-extremity pain
Journal of Anesthesia, 12/17/09
Today in Pharmacology/kinetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Use of sedatives in the critically ill
Anaesthesia & intensive care medicine, 12/17/09
The incidence of sub-optimal sedation in the ICU: a systematic review
Critical Care, 12/17/09
Obstetric analgesia: a comparison of patient-controlled meperidine, remifentanil, and fentanyl in labour
British Journal of Anesthesia, 12/16/09
Article Search
Sponsor