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What makes a molecule an anaesthetic? Studies on the mechanisms of anaesthesia using a physicochemical approach
British Journal of Anesthesia, 05/13/09
Sear JW - Recent studies of mechanisms of anaesthesia have been mainly ‘target orientated’, investigating the activity of both volatile and i.v. agents at putative sites of action. The present data suggest that, for the i.v. agents, it may be difficult to separate immobilizing (anaesthetic) activity and cardiovascular depression within a single molecule.
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