HIV-1 Proteins Preferentially Activate Anti-Inflammatory M2-Type Macrophages
The Journal of Immunology,

Takashi C et al. – Nef reduced the expression of CD163 and phagocytosis, the characteristic markers of M2–Mφ, indicating that Nef drives an M2–like to M1–like phenotypic shift. Because the differentiation of most tissue Mφ depends on M–CSF and its receptor, which is the essential axis for the anti–inflammatory M2–Mφ phenotype, the current study reveals an efficient mechanism by which HIV–1 proteins, such as Nef, induce the proinflammatory Mφ.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Allergy/Immunology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Allergy/Immunology Articles

Indexed Journals in Allergy/Immunology: Allergy, Clinical Immunology, Annals of Allergy, Asthma, and Immunologymore