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Pathogenesis and Treatment of Pruritus
Current Allergy and Asthma Reports, 05/06/2010
Greaves MW – The pathophysiology of pruritus in neurogenic itch caused by common systemic diseases is gradually being elucidated, especially in the itch of cholestasis, although the molecular basis of itching in chronic renal failure remains elusive. Better understanding of the mediators of itch and their receptors has led to the imminent development of novel anti–itch compounds, including interleukin–31 inhibitors, histamine H4–receptor antagonists, and neurokinin–1 receptor antagonists.