Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a model of chronic lung infection
Clinical and Experimental Immunology, 08/01/2012
Christophersen LJ et al. – The authors have established a model enabling studies of host responses in different pulmonary zones. An effective recognition of and a more pronounced host response to infection in the peripheral zones, indicating increased lung damage was demonstrated. Therefore, treatment of the chronic P. aeruginosa lung infection should primarily be directed at the peripheral lung zone by combined i.v. and inhalation antibiotic treatment.