Immunological mechanisms for desensitization and tolerance in food allergy
Seminars in Immunopathology , 08/01/2012
Rachid R et al. – The mechanisms underlying successful food desensitization are also unclear, in part, because there is no standard immunotherapy protocol. The mechanisms involved, however, may include mast cell and basophil suppression, development of food–specific IgG4 antibodies, reduction in the food–specific IgE/IgG4 ratio, up–regulation and expansion of natural or inducible regulatory T cells, a skewing from a Th2 to a Th1 profile, and the development of anergy and/or deletion in antigen–specific cells.