Antibodies to Wheat High-Molecular-Weight Glutenin Subunits in Patients with Celiac Disease
International Archives of Allergy and Immunology, 07/17/2012
Ellis HJ et al. – Patients with untreated celiac disease (CD) have raised antibody levels to high–molecular–weight (HMW)– glutenin subunits (GS)–1Dy10, indicating the participation of these proteins in the adaptive immune response to gluten. Discrimination between CD patients and controls is not enhanced by deamidation of HMW–GS–1Dy10. Thus antibodies to these proteins are not useful markers for CD detection.