Stromal-derived IL-6 alters the balance of myeloerythroid progenitors during Toxoplasma gondii infection
Journal of Leukocyte Biology, 07/05/2012
Chou DB et al. – Comparing the BM with the spleen showed that the hematopoietic response was driven by the local microenvironment, and BM chimeras demonstrated that radioresistant cells were the relevant source of IL–6 in vivo. Finally, direct ex vivo sorting revealed that VCAM+CD146lo BM stromal fibroblasts significantly increase IL–6 secretion after infection. These data suggest that BMSCs regulate the hematopoietic changes during inflammation via IL–6.