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A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia
European Journal of Immunology, 06/15/2012
Ordonez–Rueda D et al. – The study demonstrates that a hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia characterized by a split pattern of functional responses, reflecting the distinct thresholds required for eliciting neutrophil–mediated inflammatory and anti–infectious responses.
