Activation of cytokines corroborate with development of inflammation and autoimmunity in thromboangiitis obliterans patients.
Clinical and Experimental Immunology, 06/15/2012
Dellalibera–Joviliano R et al. – The results indicate an increased production of cytokines in Thromboangiitis obliterans (TAO) possibly contributing to the inflammatory response observed in vascular level of patients. In addition, the increased levels of IL–17 and IL–23 suggest that the disturbance of TAO is involved with mechanisms of autoimmunity. Thus, the discovery of IL–17 and its association with inflammation and autoimmune pathology has reshaped the viewpoint regarding the pathogenesis of TAO, which previously was based on T helper 1 (Th1)–Th2 paradigm.