HIV-1 drug resistance at virological failure versus immunological failure among patients failing first-line antiretroviral therapy in a resource-limited setting
International Journal of STD & AIDS, 06/15/2012
Sungkanuparph S et al. – Nucleoside reverse transcriptase inhibitor (NRTI)–, non–NRTI– and protease inhibitor–resistance–associated mutations (RAMs) were observed in 57.9%, 94.7% and 5.3%, respectively. Q151M, a multidrug RAM, was more commonly observed in the IF group (14.8% versus 2.9%, P = 0.032). Using IF to diagnose treatment failure is associated with higher HIV–1 RNA levels and a higher rate of Q151M, which can limit the options for second–line ART.