The majority of allergen-specific IgE in the blood of allergic patients does not originate from blood-derived B cells or plasma cells

Clinical & Experimental Allergy, 05/10/2012

The finding that the majority of allergen–specific IgE in the peripheral blood is not derived from IgE–secreting cells in the blood suggests local IgE production in tissues as a major source for allergen–specific IgE and possible target for therapeutic intervention.

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