Preventive immunization of aged and juvenile non-human primates to beta-amyloid
Journal of Neuroinflammation, 05/04/2012
Kofler J et al. – The results indicate that preventive Abeta immunization is a safe therapeutic approach lacking adverse CNS immune system activation or other serious side–effects in both aged and juvenile NHP cohorts. A significant shift in the composition of soluble oligomers towards smaller species might facilitate removal of toxic Abeta species from the brain.