Synchronization of Dendritic Cell Activation and Antigen Exposure Is Required for the Induction of Th1/Th17 Responses Full Text
The Journal of Immunology, 05/18/2012
Kamath AT et al. – Using adoptively transferred OT–2 cells, the authors show that the Ag targeting of lymph nodes (LN) dendritic cell (DC) prior to their activation generates nonactivated Ag–pulsed DCs that recruit Ag–specific T cells, trigger their initial proliferation, but interfere with Th1 induction in a dose–dependent manner. Thus, the synchronization of DC targeting and activation is a critical determinant for Th1/Th17 adjuvanticity.