Amplification of Toll-like receptor-mediated signaling through spleen tyrosine kinase in human B-cell activation
The Journal of Allergy and Clinical Immunology, 05/01/2012
Iwata S et al. – Syk–mediated BCR signaling is a prerequisite for optimal induction of TLR9 and TRAF6, allowing efficient propagation of TLR9–mediated signaling in memory B cells. These results also underscore the role of Syk in aberrant B–cell activation in patients with autoimmune diseases.