Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

Retrovirology, 04/27/2012

Based on these findings, authors propose that this highly conserved three amino acid VGF motif together with the acidic cluster and the proline–rich motif form a previously unrecognized amphipathic surface on Nef. This surface appears to be essential for the majority of Nef functions and thus represents a prime target for the pharmacological inhibition of Nef.

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