Transcriptomic analysis of placenta affected by antiphospholipid antibodies: following the TRAIL of trophoblast death
Journal of Reproductive Immunology, 05/11/2012
Pantham P et al. – Antiphospholipid antibodies, a maternal risk factor for preeclampsia, increase shedding of necrotic trophoblast debris from the placenta, leading to endothelial dysfunction. The results may help to understand how antiphospholipid antibodies affect trophoblast cell death and how the antibodies could contribute to the pathogenesis of preeclampsia.