Spirometry and forced oscillations in the detection of airway hyperreactivity in asthmatic children
Pediatric Pulmonology,  Clinical Article

Petak F et al - The findings demonstrate that forced oscillation technique (FOT) is as suitable as spirometry for the measurement of bronchoconstriction and thus it may be considered for the detection of airway hyperreactivity (AH) in asthmatic children. Since its application requires minimal cooperation, this approach imposes less stress and may be particularly favorable in the diagnosis of asthma at a young age.

Methods
  • FOT and spirometry were performed in 20 asthmatic children (aged 5-18years) following aerosolized histamine and methacholine at an interval of 2weeks.
  • The respiratory system input impedance was measured by FOT; the resistance at 6Hz (R6), the average resistance between 4 and 24Hz, the area under the reactance curve (AX) and the resonant frequency were extracted from these recordings.
  • Spirometry was used to obtain forced expiratory volumes and flow parameters.

Results
  • Following provocation with the two agonists, the FOT detected the airway response as early as spirometry.
  • When the greater variability of the impedance parameters was taken into account, the two methods were observed to have similar sensitivities.
  • Among the lung function parameters studied, AX and R6 were the most sensitive for the demonstration of AH.

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